• Several lines of evidence suggest that mitochondrial insuffi

  2018-11-08

  

  Several lines of evidence suggest that mitochondrial insufficiency and failure to leave glycolysis (Warburg metabolism) are the fundamental limits to normal differentiation after FGF4 removal. These lines of evidence also pinpoint the two lineages at the labyrinthine surface as the highest energy- a

• The following are the supplementary data related to

  2018-11-08

  

  The following are the supplementary data related to this article. Acknowledgments This work was supported by Marie-Curie IEF FellowshipPIEF-GA-2009-254644 (J.F.) and the Netherlands Institute for Regenerative Medicine (NIRM) (E.W., M. vd. B. and T.N.). Introduction Human ES (hES) cells are p

• Our results are in line with

  2018-11-08

  

  Our results are in line with previous findings showing that cellular senescence negatively correlates with reprogramming efficiency (Banito et al., 2009; Mali et al., 2008; Qin et al., 2007; Zhao and Daley, 2008; Zhao et al., 2008). The expression of p21 is controlled by p53 during the replicative s

• Unlike these previous methods the S

  2018-11-08

  

  Unlike these previous methods, the 3S reprogramming system generates partially reprogrammed iPSCs in a reproducible and predictable manner by regulating the amount of KLF4. These Q-VD-Oph resume reprogramming upon increased KLF4 expression and therefore are not aberrantly reprogrammed but have paus

• Myofibrils are the smallest subunit of the cardiomyocyte con

  2018-11-08

  

  Myofibrils are the smallest subunit of the cardiomyocyte contractile apparatus and consist of sarcomeres (single contractile units) in series. Here we present a method to measure the mechanical properties of single myofibrils isolated from hiPSC-CMs by a fast solution switching method (Colomo et al.

• Many prior studies have investigated individual level predic

  2018-11-07

  

  Many prior studies have investigated individual-level predictors of 2009 A(H1N1) pandemic pitavastatin acceptance. For example older age, higher education, belonging to an ethnic majority, belonging to a priority group, receiving recommendations from a health professional, receiving information fro

• Similarly the evidence suggesting an association between bil

  2018-11-07

  

  Similarly, the evidence suggesting an association between bilingualism and a delay in the onset of Alzheimer’s disease (AD) and other forms of dementia is also mixed. In the first study exploring this relation, Bialystok et al. (2007) divided a sample of 184 patients with dementia (most of whom were

• br El sistema financiero Los resultados

  2018-11-07

  

  El sistema financiero Los resultados de las pruebas de estrés del BCE muestran que los cuatro bancos con malos resultados lograron mejorar su nivel de capital histone methyltransferase lo largo del año 2014 (COFACE, 2015). Para medir el riesgo sistémico el BCE publica el indicador compuesto de es

• In Fig countries are ranked

  2018-11-07

  

  In Fig. 1, countries are ranked by the percentage of (normalized) negative sentiment expressed towards a given question. (All figures quoted are normalized responses.) Respondents from Bangladesh (0.3%), Ecuador (0.4%), and Iran (0.5%) report the lowest levels of importance-related skepticism, whils

• br Materials Methods br Results We

  2018-11-07

  

  Materials & Methods Results We sequenced the exomes of 59 Greek (GR) and 15 German (DE) patients with validated bacterial sepsis/organ dysfunction according to the new Sepsis-3 definition (Seymour et al., 2016; Shankar-Hari et al., 2016; Singer et al., 2016). Each cohort included two groups of

• br Introduction Neurofibromin Merlin NF is a tumour suppress

  2018-11-07

  

  Introduction Neurofibromin 2 (Merlin, NF2) is a tumour suppressor protein expressed during embryonic development and thereafter (Gronholm et al., 2005). In adults, significant levels of expression are found in Schwann and meningeal cells, nerve and lens (Claudio et al., 1997; Sakuda et al., 1996;

• The majority of pharmacogenetic studies

  2018-11-07

  

  The majority of pharmacogenetic studies are performed in Asian and Caucasian populations; data generated in African-American populations are sometimes extrapolated to represent the population of the African continent. However, the ancestry of African-Americans is predominantly from Niger-Kordofanian

• In the publication by Sampath et

  2018-11-07

  

  In the publication by Sampath et al. () several lung transplant patients were identified with infections in association with pleuritic, surgical site infection and/or mediastinitis. These findings are unexpected to some degree, as historically has often been dismissed as normal genital flora (). How

• Since persistent telomeric DNA damage is a feature

  2018-11-07

  

  Since persistent telomeric DNA damage is a feature of replicative, stress- and oncogene-induced senescence, it has been suggested that unrepaired telomeres provide a source of persistent DDR signaling which is important to the establishment of senescence (Fumagalli et al., 2012). However, damage at

• The depleted RNA was fragmented using RNase III

  2018-11-07

  

  The depleted RNA was fragmented using RNase III in preparation for amplification of the cDNA library, which was produced by reverse transcription from adapters attached to the ends of the RNA molecules, in accordance with the SOLiD™ Total RNA-Seq kit protocol (Life Technologies™, CA). Next, 6% denat

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