• Annexin V-FITC/PI Apoptosis Assay Kit: Novel Insights for...

  2025-09-23

  This article explores the application of the Annexin V-FITC/PI Apoptosis Assay Kit in dissecting the interplay between autophagy and apoptosis, with a focus on mechanisms relevant to renal cell carcinoma. Emphasizing technical rigor, it highlights how precise apoptosis assay techniques advance cell death pathway analysis in oncology.

• Annexin V as a Phosphatidylserine Binding Protein in Immu...

  2025-09-22

  Explore the multifaceted role of Annexin V—a phosphatidylserine binding protein—in dissecting immune cell apoptosis, immune tolerance, and disease modeling. This article spotlights Annexin V’s application as an apoptosis detection reagent in advanced research fields.

• Nitrocefin as a Chromogenic Tool for β-Lactamase Mechanis...

  2025-09-19

  Explore the advanced applications of Nitrocefin, a chromogenic cephalosporin substrate, in dissecting β-lactamase enzymatic activity and antibiotic resistance mechanisms in novel pathogens such as Elizabethkingia anophelis. This article provides a rigorous analysis of Nitrocefin's role in β-lactamase detection and inhibitor screening, with reference to recent biochemical studies.

• Annexin V in Immune Cell Apoptosis: Novel Insights for Di...

  2025-09-18

  Explore how Annexin V, a phosphatidylserine binding protein, advances apoptosis detection and mechanistic studies in immune cell death. This article highlights its application in immune regulation research, with emphasis on translational disease models and recent findings.

• This chemistry paved way for

  2025-03-03

  

  This chemistry paved way for multi-gram synthesis of which was utilized for extensive piperazine benzamide SAR exploration. Depicted in , the two-step operation towards final targets involved standard amide coupling conditions with EDC or HATU followed by Boc deprotection under acidic conditions. S

• The literature suggests that adiponectin has

  2025-03-03

  

  The literature suggests that adiponectin has a steroidogenic effect on ovarian function. In pigs, in vitro studies have shown that adiponectin reduced basal testosterone secretion in internal theca cells; in granulosa cells, it increased secretion of estradiol and, in combination with insulin, incre

• It is reported that Adiponectin

  2025-03-03

  

  It is reported that Adiponectin is able to suppress NF-κB pathway, and Bcr-Abl fusion oncoprotein in CML activates NF-κB by stimulating its nuclear translocation and also by enhancing its transactivation function [25], [26]. Therefore, it is tempting to hypothesize that NF-κB pathway might be involv

• br Acknowledgement This work was supported by grants

  2025-03-03

  

  Acknowledgement This work was supported by grants from the American Heart Association Scientist Development Grant (SDG) to A. Elmarakby and 1R01EY023315-01 award to M. Al-Shabrawey. Introduction Inflammatory response is the result of a complex interaction between immune Aloe vera extract and

• The adoptive transfer experiments additionally demonstrated

  2025-03-03

  

  The adoptive transfer experiments additionally demonstrated the role of cholinergic regulation in the antibody immune response. Injection of LPI-stimulated B lymphocytes significantly up-regulated both the IgM and IgG responses to cytochrome c in the host. Obviously, this effect was due to activatio

• br Patients and Methods br Results br

  2025-03-03

  

  Patients and Methods Results Discussion Gjerdrum et al showed that Axl CC-115 is required to maintain the mesenchymal-like invasiveness of metastatic breast carcinoma cells, but Axl knockdown has no effect on the cell proliferation of MDA-MB-231 cells. Mackiewicz et al also showed that down

• Based on these findings the time

  2025-03-03

  

  Based on these findings, the time point for manipulating autophagy may also determine its role, whereby autophagy induction performed before ischemia could play a protective role but have an opposite effect once ischemia/reperfusion has occurred. This hypothesis is further supported by the protectiv

• Recent progress has been made in translating animal

  2025-03-01

  

  Recent progress has been made in translating animal findings on memory performance and amnestic effects – that are largely determined by tonically active receptors in which α5 contributes to the benzodiazepine binding site. Based on the observation that deletion of this subunit led to improved spati

• Over the years measures of total

  2025-03-01

  

  Over the years, measures of total antioxidant status (TAS) have been developed to capture the collective effect of antioxidant defense capacity, including enzymatic and nonenzymatic systems (Fraga et al., 2014, Franco et al., 2007). Multiple antioxidant enzymes, as well as antioxidant vitamins and m

• Introduction Heterotrimeric G proteins mediate signal transd

  2025-03-01

  

  Introduction Heterotrimeric Gαβγ proteins mediate signal transduction through seven-transmembrane domain receptors. In response to neurotransmitters or hormones, activated receptors bind GTP via the Gα subunit leading to the dissociation of Gα from the Gβγ dimer. G proteins regulate the levels of s

• br Duality of interest br Contribution statement br

  2025-03-01

  

  Duality of interest Contribution statement Acknowledgments Introduction Rapid, cell surface-initiated steroid actions have been reported for all major groups of steroid hormones and our understanding of membrane-mediated steroid actions has progressed rapidly over the last two decades. M

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